纵观整项研究，我们不仅看到了FOCAS这一强大工具的威力，更看到了它所揭示的生物学复杂性。过去针对m6A的抗癌策略往往类似于“地毯式轰炸”（如全局抑制METTL3或FTO），虽然有效，但伴随着破坏管家功能的风险。

2026年1月2日凌晨3点，西湖大学生命科学学院曹龙兴实验室、西湖大学医学院解明岐实验室合作在Science上发表了题为：“De novo design of small molecule–regulated protein oligomers” ...

Much of the phenotypic variation that is observed within and between species is the result of differences in gene regulation: specifically when, where and how much the genes are expressed. Given the ...

12月31日，北京大学以“FOCAS: Transcriptome-wide screening of individual m6A sites functionally dissects epitranscriptomic control of ...

This study presents SynaptoGen, a differentiable extension of connectome models that links gene expression, protein-protein interaction probabilities, synaptic multiplicity, and synaptic weights, and ...

To help achieve more precise control of gene therapy, engineers have designed a new control circuit that can keep gene expression levels within a target range. The method could be used to deliver ...

What if you could flip a genetic switch to silence a gene, then turn it back on with a simple drug? For researchers, gene-switch tools offer that kind of control—and a new system called Cyclone may ...

Investigators at Weill Cornell Medicine have developed a versatile and non-toxic technology for controlling the activity of any gene in a cell. Such "gene-switch" tools allow scientists to "turn on" ...

Genes make up the blueprints and outline the process of building every living organism. To ensure that the right genes are activated in the right cells, and in the right amounts at the right time, ...

A research team has identified the core gene expression networks regulated by key proteins that fundamentally drive phenomena such as cancer development, metastasis, tissue differentiation from stem ...